Year : 2019  |  Volume : 10  |  Issue : 3  |  Page : 140-143

Effect of interval and continuous training on proliferator-activated receptor gamma coactivator-1α and lactate dehydrogenase B levels in adult rat heart

1 Department of Medical Physiology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
2 Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia

Correspondence Address:
Ermita I Ibrahim Ilyas
Jalan Salemba Raya No. 6, Jakarta Pusat 10430
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jnsbm.JNSBM_69_19

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Introduction: Mitochondrial biogenesis is affected by peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α) and can be induced through physical exercise. Lactate from the skeletal muscle produced in the heart during exercise can be used as an energy source through conversion by lactate dehydrogenase B (LDH B). This study compared the effects of continuous training (CT) and interval training (IT) on PGC-1α and LDH B levels in the adult rat hearts. Materials and Methods: Fifteen male adult Wistar rats (12 months old) were randomly divided into three groups as follows: A control Group (c), a CT group and an IT group. Training was conducted using a rodent treadmill, 5 days/week for 8 weeks. The duration was 50 min for the CT group. In the IT group, training consisted of 4 bouts of 4 min of exercise, followed by rest intervals of 1 min. Speed was increased each week. After 8 weeks of training, the rats were sacrificed, and the levels of PGC-1α and LDH B in heart tissue were measured using enzyme-linked immunosorbent assay. Results: Differences in PGC-1α levels between groups were statistically significant (P = 0.008), while differences in LDH B levels were not statistically significant (P = 0.063). Levels of PGC-1α and LDH B were higher in the CT group than in the IT group. Conclusion: We concluded that CT has a greater effect on energy metabolism in the heart than IT.

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