Year : 2015  |  Volume : 6  |  Issue : 2  |  Page : 335-339

Toxic effects of Mn 2 O 3 nanoparticles on rat testis and sex hormone

1 Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2 Department of Biology, Payame Noor University, Isfahan, Iran
3 Young Researchers and Elite Club, Khorasgan Branch, Islamic Azad University, Isfahan, Iran

Correspondence Address:
Dr. Marziyeh Ajdary
Young Researchers and Elite Club, Khorasgan Branch, Islamic Azad University, Isfahan
Login to access the Email id

Source of Support: Expenses of this work were discharged by authors., Conflict of Interest: None

DOI: 10.4103/0976-9668.159998

Rights and Permissions

Background and Objective: The safety of Mn 2 O 3 nanoparticles (which are extensively used in industries) on male reproductive system is not known. Hence, we investigated the effects of Mn 2 O 3 nanoparticles on male reproductive system. Materials and Methods: A total of 40 Wistar adult male rats were randomly assigned to four groups of 10 rats each. Three groups received Mn 2 O 3 solution in concentrations of 100, 200, and 400 ppm orally for 14 days; the control group received equal volume of saline solution. Blood samples and testicles were collected for analysis. Results: Significant reduction in luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone, spermatogonial cells, primary spermatocyte, spermatid and Leydig cell was observed in the Mn 2 O 3 nanoparticles treated groups compared with controls. Conclusion: Mn 2 O 3 nanoparticles significantly reduce FSH, LH, and testosterone levels resulting in a significant reduction in testicular cytology.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded238    
    Comments [Add]    
    Cited by others 2    

Recommend this journal