CASE REPORT
Year : 2015  |  Volume : 6  |  Issue : 1  |  Page : 245-247

A rare case of clear cell variant of oral squamous cell carcinoma


1 Department of Oral and Maxillofacial Pathology, Chettinad Dental College and Research Institute, Chettinad Health City Campus, Kelambakkam, Kancheepuram, Tamil Nadu, India
2 Department of Oral and Maxillofacial Surgery, Chettinad Dental College and Research Institute, Chettinad Health City Campus, Kelambakkam, Kancheepuram, Tamil Nadu, India

Correspondence Address:
Dr. Sriram Kaliamoorthy
Department of Oral and Maxillofacial Pathology, Chettinad Dental College and Research Institute, Chettinad Health City Campus, IT-Highway Chennai, Kelambakkam - 603 103, Kancheepuram, Tamil Nadu
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0976-9668.149209

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Oral squamous cell carcinoma with prominent clear cell differentiation is a rare occurrence. A 35-year-old female patient presented with a nonhealing ulcer persistent for 1-month involving the left lateral border of the tongue and lingual vestibule. Lobules of malignant squamous epithelial cells with abundant cytoplasm and vesicular nuclei in the connective tissue were observed following histopathology. Neoplastic cells constituting majority of lobules exhibited clear cell changes. Periodic acid-Schiff and mucicarmine stains showed negative reaction. Immunohistochemical study using antibody for cytokeratin, revealed diffuse and intense positivity. The neoplastic cells showed complete negative reaction with antibodies for vimentin, smooth muscle actin and homatropine bromide-45 antigens.


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