| RESEARCH ARTICLE |
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| Year : 2015 | Volume
: 6
| Issue : 1 | Page : 183-187 |
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Antioxidant and protective effects of Phytocee™ against carbon tetrachloride-induced oxidative stress
Joshua Allan Joseph1, Uma Radhakrishnan2, Sridhar Mutyala3, Krishnagouda Shankargouda Goudar3, Usha Parackal Thachappully Ayyappan1, Amit Agarwal3
1 Department of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal Sciences, Mannuthy, Thrissur, Kerala, India
2 Department of Veterinary Biochemistry, College of Veterinary and Animal Sciences, Mannuthy, Thrissur, Kerala, India
3 Department of Pharmacology and Toxicology, R and D Center, Natural Remedies, Bengaluru, Karnataka, India
Correspondence Address:
Dr. Joshua Allan Joseph
Department of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal Sciences, Mannuthy, Thrissur - 680 651, Kerala
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0976-9668.149119
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Background: This study evaluated the antioxidant potential of a polyherbal formulation (Phytocee™ ) in the rodent model. Materials and Methods: Four groups of rats (n = 6) were pretreated with Vitamin C (20 mg/kg) or Phytocee™ (20, 100, and 200 mg/kg), respectively for 10 days. Oxidative stress in rat liver was induced by administration of carbon tetrachloride (CCl 4 ) at 2 ml/kg as a single dose orally to all groups except the vehicle control group. After 24 h of administration of CCl 4 , hepatic levels of malondialdehyde (MDA), serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), hepatic superoxide dismutase (SOD), catalase, and reduced glutathione (GSH) levels were evaluated.
Results: Phytocee™ administered groups at all the dose levels significantly reduced the hepatic MDA, serum ALT and AST levels with a marked increase in hepatic SOD and catalase as compared with CCl 4 treated group. Conclusion: The findings suggest that Phytocee™ markedly reversed the effects of CCl 4 induced oxidative stress and can be used as an antioxidant feed supplement. |
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