Year : 2012  |  Volume : 3  |  Issue : 2  |  Page : 125-132

Nardostachys jatamansi extract prevents chronic restraint stress-induced learning and memory deficits in a radial arm maze task

1 Department of Applied Zoology, Mangalore University, Mangalore, Karnataka, India
2 Department of Physiology, K. S. Hegde Medical Academy, Mangalore, Karnataka, India
3 Department of Pharmacology, K. S. Hegde Medical Academy, Mangalore, Karnataka, India

Correspondence Address:
K S Karanth
Emeritus Professor, Department of Pharmacology, K. S. Hegde Academy of Medical Sciences, Nitte University, Nithyanandanagar, Mangalore 575 018, Karnataka
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0976-9668.101879

Rights and Permissions

Nardostachys jatamansi is traditionally used in alternative medicine for treatment of neuropsychiatric disorders. We investigated the potential of N. jatamansi extract (NJE) in protecting against chronic stress-induced impairments in spatial learning and memory. The rats were exposed to 21 days of chronic restraint stress and simultaneously received 100 mg or 200 mg/kg body weight of NJE following which acquisition and retention of hippocampus-dependent spatial memory were tested in a partially-baited eight arm radial maze. Animals treated with 200 mg/kg body weight NJE had learning curves comparable to control unstressed animals, made significantly more correct choices (38%, P < 0.001), and fewer reference memory errors (53%, P < 0.01) on the eighth day of training compared to untreated stressed animals as well as stressed animals which received vehicle or a lower dose (100 mg/kg) of NJE. NJE-treated animals also made significantly higher correct choices (31%, P < 0.001) than untreated animals in a retention test 10 days after the training period. We propose that NJE has a protective effect of stress-induced impairments in hippocampus-dependent learning and memory behavior in rats.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded597    
    Comments [Add]    
    Cited by others 15    

Recommend this journal