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A review on the therapeutic potential of embryonic and induced pluripotent stem cells in hepatic repair
K Ananda Krishna1, K Sai Krishna2, Ruben Berrocal3, Alekya Tummala4, KS Rao3, K.R.S. Sambasiva Rao5
1 Department of Biotechnology, Acharya Nagarjuna University, Guntur, India
2 Department of Biotechnology, Meenakshi Medical College and Research Institute, Enathur, Kancheepuram, Tamilnadu, India
3 Institute for Scientific Research and Technology Services, National Secretariat for Science, Technology and Innovation, Clayton City of Knowledge, Republic of Panama
4 Department of Clinical Biochemistry, Columbus College of Medicine, Republic of Panama
5 Department of Biotechnology, Acharya Nagarjuna University, Guntur, India; Institute for Scientific Research and Technology Services, National Secretariat for Science, Technology and Innovation, Clayton City of Knowledge, Republic of Panama
Correspondence Address:
K.R.S. Sambasiva Rao
Institute for Scientific Research and Technology Services, National Secretariat for Science, Technology and Innovation, Clayton City of Knowledge, 0843-01103, Republic of Panamá
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0976-9668.92314
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Despite the liver being proliferatively quiescent, it maintains balance between cell gain and cell loss, invokes a rapid regenerative response following hepatocyte loss, and restores liver mass. Human liver has immense regenerative capacity. Liver comprises many cell types with specialized functions. Of these cell types, hepatocytes play several key roles, but are most vulnerable to damage. Recent studies suggest that the extrahepatic stem cell pool contributes to liver regeneration. Stem cell therapies have the potential to enhance hepatic regeneration. Both embryonic and induced pluripotent stem cells could be a suitable source to regenerate hepatocytes. In the present review, we discuss the therapeutic potential of stem cells in hepatic repair and focus on the clinical applications of stem cells. |
