Year : 2011  |  Volume : 2  |  Issue : 1  |  Page : 76-79

Phytochemical investigation and evaluation of antinociceptive activity of ethanolic extract of Dalbergia sissoo (Roxb.) bark

Department of Pharmacy, Faculty of Pharmacy, GRD (PG) IMT Rajpur, Dehradun - 248 901, Uttarakhand, India

Correspondence Address:
Mohammad Asif
Department of Pharmacy, Faculty of Pharmacy, GRD (PG) IMT, Rajpur, Dehradun - 248 901, Uttarakhand
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0976-9668.82315

Rights and Permissions

The antinociceptive activity of ethanolic extract of the plant bark of Dalbergia sissoo (Roxb.) was investigated using tail flick method on Wistar rats. Three different dose levels (300, 500, and 1000 mg/kg) in 0.5% carboxyl methyl cellulose (CMC) were administered by p.o. route. The antinociceptive activities of the all doses were compared with that of the standard drug asprin (300 mg/kg) administered by p.o. route and the results were found to be significant (P < 0.01). At the above doses, the extract exhibited significant and dose-dependent antinociceptive activity. Phytochemical investigation of the ethanolic extract indicated the presence of carbohydrates, proteins, amino acids, phenolic compounds, and flavanoids. The antinociceptive activity of the bark extract of D. sissoo may be due to the presence of phytochemical constituents such as flavanoids. The acute toxicity study revealed that ethanolic extract was not toxic up to 3000 mg/kg body weight.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded633    
    Comments [Add]    
    Cited by others 10    

Recommend this journal