Journal of Natural Science, Biology and Medicine

ORIGINAL ARTICLE
Year
: 2020  |  Volume : 11  |  Issue : 1  |  Page : 39--44

High-sensitive C-reactive protein in patients with coronary artery disease


Virendra C Patil, Aniket B Avhad, Akshay R Kulkarni, Kaustubh A Pandere 
 Department of Medicine, Krishna Institute of Medical Sciences Deemed to be University, Karad, Maharashtra, India

Correspondence Address:
Dr. Virendra C Patil
Department of Medicine, Krishna Institute of Medical Sciences Deemed to be University, Karad, Maharashtra
India

Background: Inflammation plays a key role in the pathogenesis of atherosclerosis and coronary artery disease (CAD). Aim and Objectives: The aim of this study was to assess the relation of serum high-sensitivity C-reactive protein (hs-CRP) with the presence and severity of CAD. Study Design: This was a cross-sectional, observational study done on patients with diagnosis of acute coronary syndrome (ACS) undergoing coronary angiogram (CAG). Materials and Methods: A total of 100 patients were included in this study satisfying the inclusion criteria. The inclusion criteria were patients with the diagnosis of ACS undergoing CAG. All enrolled patients underwent hs-CRP, hemoglobin, serum creatinine, fasting lipid profile, blood sugar level, resting 12-lead electrocardiogram, creatine kinase–myocardial band, troponin -I, and CAG. Statistical Analysis: Data were analyzed for mean, percentage, standard deviation and Chi-square test for quantitative data using SPSS software version 21 (trial version), and P < 0.05 was considered statistically significant. Results: A total of 63% of male and 37% of female patients underwent CAG. The mean level of hs-CRP was 2.73 (±0.73) mg/L. The level of hs-CRP, severity of coronary artery involvement, and CAD risk factors was significantly more with an hs-CRP level of 1–3 mg/L followed by >3 mg/L. The significant number of patients with double-vessel disease (DVD) and triple-vessel disease (TVD) had an hs-CRP level between 1 and 3 mg/L compared to single-vessel disease (SVD) with P < 0.03. About 67.57% of females and 44.44% of males had an hs-CRP level of 1–3 mg/L, respectively (P < 0.02). A total of 53% of population had an hs-CRP level between 1 and 3 mg/L, 23% had <1 mg/L, and 24% had >3 mg/L (P < 0.02). The hs-CRP was positively correlated with severity of CAD by angiogram (+0.21). Conclusions: A significant number of patients had an hs-CRP level of 1–3 mg/L. The severity of CAD was positively correlated with a level of hs-CRP in incremental fashion. Patients with DVD and TVD had a high hs-CRP level compared to SVD. The hs-CRP can be considered as novel CAD risk factors to be screened in the patients with CAD where it cannot be forecasted by traditional risk factors.


How to cite this article:
Patil VC, Avhad AB, Kulkarni AR, Pandere KA. High-sensitive C-reactive protein in patients with coronary artery disease.J Nat Sc Biol Med 2020;11:39-44


How to cite this URL:
Patil VC, Avhad AB, Kulkarni AR, Pandere KA. High-sensitive C-reactive protein in patients with coronary artery disease. J Nat Sc Biol Med [serial online] 2020 [cited 2020 Sep 18 ];11:39-44
Available from: http://www.jnsbm.org/article.asp?issn=0976-9668;year=2020;volume=11;issue=1;spage=39;epage=44;aulast=Patil;type=0