Journal of Natural Science, Biology and Medicine

: 2015  |  Volume : 6  |  Issue : 2  |  Page : 283--285

Advancement in biochemical diagnostics and regenerative medicine leading to integration of dentistry into 360° health program

Anbuselvan G Jegatheeswaran1, Arun H. S. Kumar2,  
1 Indian Academy of Dental Specialist, Tamil Nadu, India
2 Editor in Chief, Journal of Natural Science, Biology and Medicine, University College Dublin, Dublin, Ireland

Correspondence Address:
Arun H. S. Kumar
Editor in Chief, Journal of Natural Science, Biology and Medicine, University College Dublin, Dublin

How to cite this article:
Jegatheeswaran AG, Kumar AH. Advancement in biochemical diagnostics and regenerative medicine leading to integration of dentistry into 360° health program.J Nat Sc Biol Med 2015;6:283-285

How to cite this URL:
Jegatheeswaran AG, Kumar AH. Advancement in biochemical diagnostics and regenerative medicine leading to integration of dentistry into 360° health program. J Nat Sc Biol Med [serial online] 2015 [cited 2020 Sep 22 ];6:283-285
Available from:

Full Text


Over the last decade, dentistry has taken many leaps influenced by scientific development in several collateral areas of research, including regenerative medicine and biochemical diagnostics. Hence, in this issue continuing our miniseries section, we have included a few articles in the broad areas of dentistry. Beginning this miniseries is an article assessing the medical knowledge among dental surgeons on the potential ocular complications of intraoral local anesthesia, which is a routinely used procedure in dental practice. It is indeed surprising to note that several gaps exist in the knowledge among clinicians that necessitate the need for more effective continuous professional development/educational programs. Although several such programs are currently available in various formats, it seems that these formats are not effective. Adopting traditional approaches of knowledge delivery (monographs, books, seminars, conference, etc.), may lead to ineffectiveness of these programs as often due to busy professional commitments these traditional formats of knowledge delivery may have practical limitations. One way to overcome this limitation may be the use of online education that has gained considerable momentum recently, with several corporates getting involved in developing platforms for delivering online education. The benefits of accessing the online educational resources at ones convenience will prove to be highly useful and efficient in continuous professional development/educational programs for busy clinicians. We hope the concerned professional organization gives some thought toward developing such vital and necessary online educational resources aligned to recent advancements and updates in the developing nations. We also have an article on the potential of bone grafts in promoting tissue regeneration, which may have several applications easily adoptable to dental clinical practice. Another article in this issue looks at a nonconventional approach to predict those patients prone to the development of dental caries using finger print patterns. Many studies have looked into association of finger print patterns with some clinical conditions. Such associations, if proved beneficial in predicting the disease development, may find immense applications in not only personalized medicine but also in adopting early intervention of preventive measures, a concept which we refer to as 360° health program (treating the patient rather than the disease). We also have included an article on the rugae patterns in a South Indian population, highlighting the utility and need to document such parameters in forensic dentistry and perhaps for understanding human evolution. Indeed another article in this miniseries discusses the estimation of predentin thickness in understanding developing and developed permanent teeth, thus supporting the role of developmental dentistry in understanding dental anomalies. In alignment with the 360° health program, an article in this miniseries reports the incidence of oral candidal inflection among patients with Down syndrome, which indeed highlights that while dental disorders may be associated with systemic conditions and vice versa, many systemic conditions are leading to or are associated with dental disorders.

Also supporting the 360° health program is an article on palliative approach of using vestibular stimulation in the treatment of diabetes and its complications. A concept, which again supports a patient centric approach of therapeutics. Unfortunately, this is a very under-researched area in science despite its potential benefits. Indeed the power of thought exists and ways can be created if there is a will and the central nervous system has and will have a predominant role in 360° health program. Hence, there is a need to put efforts to better understand such palliative approaches in therapeutics. Tuberculosis is yet another disease with pandemic presence but has taken its toll especially in the developing nations where it is more of a lifestyle-associated disease. In this issue, we have included a comprehensive review on the recent advancements in the diagnosis and treatment of tuberculosis in childhood. Despite the extent of diagnostic and therapeutic advancements, the utility of these improvements can be significantly undermined if the knowledge is not effectively disseminated to the patients and the medical fraternity. Reflecting this concern is an article highlighting the lack of awareness among the concerned patients on cervical cancer, which may lead to under or delay in utilization of the available treatment. Hence, it is time that effective online education platforms are utilized to disseminate health-related information as part of public health measures. The need for such public health initiatives is evident from three more articles in this issue, highlighting the lack of perception on health impact of obesity and lifestyle patterns, impact of fast food consumption, and physical inactivity as a major risk for obesity and hypertension and in contrast malnutrition-associated health issues among various groups, especially in the Middle Eastern and Asian populations. This is indeed a cause for concern, which needs immediate public health measures to address this potential health catastrophe.

In this issue, we have also included a few articles on novel biochemical diagnostic approaches. One article highlights the utility of gingival crevicular fluid as a vital biochemical tool to assess the progression of dental therapy. Several other studies have previously reported the utility of gingival blood samples in the diagnosis of diabetes and other inflammatory conditions. Also included in this issue is an article indicating the reliability of lipid profiles rather than inflammatory markers such as C-reactive protein in predicting prehypertensive patients. The feasibility of early detection or prediction of disease development is lucrative in adopting appropriate preventive measures or palliative therapies and hence, early implementation of 360° health program. Another article in this issue also highlights the utility of antithyroid peroxidase antibodies (antiTPOAbs) as a diagnostic marker to identify potential complication during pregnancy and maternal mortality. Maternal mortality is of major health concern in the developing and underdeveloped nations, where the availability of such incidence predictive markers will be of enormous public health benefit. While biochemical-based diagnostic approaches have been in use for many years, diagnostic imaging has significantly refined the disease diagnosis process to an extent that precise differential diagnosis can be achieved using appropriate imaging modality. Highlighting this is an article reporting on the utility of magnetic resonance imaging (MRI) in differential diagnosis of tuberculosis versus pyogenic spondylodiscitis. Further refinement in the diagnosis of the disease will be achieved by merging biochemical and diagnostic imaging modalities, which is explored by several research groups globally. Needless to mention is the fact that the future of effective and efficient diagnosis will be the various imaging modalities. However, some of the imaging modalities currently used do have a certain level of risk associated with exposure to the radiations used for imaging. Surprisingly, the awareness on such radiation risks among referral physicians in a North Indian state is very inadequate, as highlighted by one of the study in this issue. Such lack of awareness can significantly compromise the health and safety of the patients and personnel working in the clinical setting. This once again emphasizes the need for effective educational programs, which can be achieved using online education platforms as has been highlighted before.

Resistance to antibiotics continues to be a pandemic issue, which if not addressed on priority may have devastating consequences on human and animal kind. In this issue, we have two articles highlighting the severity of antibiotic resistance by gram-negative bacteria and Escherichia coli (E. coli) in a tertiary care hospital setting that is of significant concern. There is an urgent need to address the issue of antibiotics resistance on a global platform. It will be interesting to see if natural and ayurvedic medicines/approaches will have any potential measures against antibiotics resistance. In this issue, we also have an article reporting on the symbiotic benefits of plant growth-promoting rhizobacteria, which may probably be an ideal biomanure to boost agricultural production. Indeed such symbiotic benefits from microbial colonies have also been recently reported in humans, which have resulted in the development of fecal transplant as a therapeutic measure. This has also led to an establishment of the novel concept on gut-brain axis and gut-cardiac axis, wherein the beneficial impact of certain microbial colonies in the gut is observed in brain and cardiac disorders. However, it remains to be seen if this beneficial gut microbial world may have any positive impact on addressing antibiotic resistance. We have also included a few articles reporting on the utility of natural and ayurvedic products in treating hepatic ischemia reperfusion injuries, anal fistulas, dental plaque, immunomodulation, peptic ulcers, and diabetes. Interestingly, nanoparticle-based approaches are being developed for therapeutic delivery of drugs including natural and ayurvedic products. However, such an approach must be addressed with caution as highlighted in one article in this issue reports the potential reproductive toxicity of magnesium nanoparticles, raising significant safety concerns.

We also have included a range of clinical case reports in this issue, both on clinical management as well as novel techniques. Some of them are a typical presentation of Plasmodium falciparum, complications of type 1 neurofibromatosis, multiple aggressive vertebral hemangioma, ridiculous premolars, glass fiber in adhesive dentistry to correct dental fractures, prosthetic management of hemimandibulectomy, femoral herniation of the female internal genitalia, fungal cause of maxillary osteomyelitis, oral Kaposi sarcoma among human immunodeficiency virus (HIV) patients, monostotic fibrous dysplasia with Raynaud's phenomenon, management of chronic suppurative osteomyelitis, utility of computerized tomography in nonsyndromic pandental anomalies, presentation of hepatocellular carcinoma as sellar mass, breast abscess caused by Staphylococcus aureus, parasitic cause of pseudo cervical carcinoma, and the potential complications of argon plasma coagulation therapy. We hope our readers will continue to benefit from the diversity of knowledge that we have included in this issue.


Anbuselvan G. Jegatheeswaran and Arun H. S. Kumar

Financial support and sponsorship


Conflict of interest

There are no conflicts of interest.