Journal of Natural Science, Biology and Medicine

ORIGINAL ARTICLE
Year
: 2013  |  Volume : 4  |  Issue : 1  |  Page : 68--73

Ameliorating effect of mother tincture of Syzygium jambolanum on carbohydrate and lipid metabolic disorders in streptozotocin-induced diabetic rat: Homeopathic remedy


Soumyajit Maiti, Kazi M Ali, Kishalay Jana, Kausik Chatterjee, Debasis De, Debidas Ghosh 
 Department of Bio Medical Laboratory Science and Management with Clinical Nutrition Unit (U.G.C. Funded Innovative Department), Vidyasagar University, Midnapore, West Bengal, India

Correspondence Address:
Debidas Ghosh
Department of Bio Medical Laboratory Science and Management, In charge of Clinical Nutrition and Dietetics Unit (U.G.C. Funded Innovative Department), Vidyasagar University, Midnapore, West Bengal
India

Background: Syzygium jambolanum (S jambolanum) is widely used in homeopathy for treating patients with diabetes mellitus. In the present study, an attempt has been made to investigate the remedial effect of homeopathic drug S jambolanum on carbohydrate and lipid metabolic disorders on streptozotocin induced diabetic rat. Materials and Methods: Diabetes induction in Wistar strain rat was performed as per standard method using streptozotocin at the dose of 4 mg/100 gm body weight. Activities of carbohydrate metabolic enzymes in hepatic tissue, and glycogen content in hepatic and muscular tissues were assessed biochemically following the standard protocols. Serum lipid profile level and activities of GOT and GPT in serum were measured as per standard method using specific kits. Results: The homeopathic drug, mother tincture of S jambolanum significantly decreased fasting blood glucose levels and improved carbohydrate metabolic key enzyme activities in hepatic tissue i.e., hexokinase, glucose-6-phosphate dehydrogenase and glucose-6-phosphatase in diabetic rats. Alongside, serum lipid profile biomarkers i.e., triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDLc), very low density lipoprotein cholesterol (VLDLc) and high density lipoprotein cholesterol (HDLc) levels were significantly ameliorated in homeopathic drug supplemented diabetic animals in compared with the untreated diabetic animal. Side by side, the S jambolanum has the capacity to attenuate diabetes induced hepatic injury in model animal, which has been assessed here by the recovery of GOT and GPT activities in serum of drug treated diabetic animal. Conclusion: The result of the present study indicated that the homeopathic drug S jambolanum (mother tincture) has a protective effect on diabetic induced carbohydrate and lipid metabolic disorders in STZ-induced diabetic animal.


How to cite this article:
Maiti S, Ali KM, Jana K, Chatterjee K, De D, Ghosh D. Ameliorating effect of mother tincture of Syzygium jambolanum on carbohydrate and lipid metabolic disorders in streptozotocin-induced diabetic rat: Homeopathic remedy.J Nat Sc Biol Med 2013;4:68-73


How to cite this URL:
Maiti S, Ali KM, Jana K, Chatterjee K, De D, Ghosh D. Ameliorating effect of mother tincture of Syzygium jambolanum on carbohydrate and lipid metabolic disorders in streptozotocin-induced diabetic rat: Homeopathic remedy. J Nat Sc Biol Med [serial online] 2013 [cited 2019 Nov 15 ];4:68-73
Available from: http://www.jnsbm.org/article.asp?issn=0976-9668;year=2013;volume=4;issue=1;spage=68;epage=73;aulast=Maiti;type=0