Journal of Natural Science, Biology and Medicine

ARTICLE
Year
: 2011  |  Volume : 2  |  Issue : 3  |  Page : 105-

The effect of diffused drug and noise in the stochastic model of rat hepatocytes


Md. Badruzzaman1, Md. Zubbair Malik1, Md. Jahoor Alam2, G Reenaroy Devi2, Ravins2, RK Brojen Singh2, Shahnawaz ali1, Fauzul Mobeen3, Faez Iqbal Khan1,  
1 Department of Computer Science, Jamia Millia Islamia, New Delhi-110025, India
2 Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi - 110025, India
3 School of Computational and Integrative Sciences, Jawaharlal Nehru University, New Delhi, India

Correspondence Address:
Shahnawaz ali
Department of Computer Science, Jamia Millia Islamia, New Delhi-110025
India




How to cite this article:
Md. Badruzzaman, Malik M, Alam M, Devi G R, Ravins, Brojen Singh R K, ali S, Mobeen F, Khan FI. The effect of diffused drug and noise in the stochastic model of rat hepatocytes.J Nat Sc Biol Med 2011;2:105-105


How to cite this URL:
Md. Badruzzaman, Malik M, Alam M, Devi G R, Ravins, Brojen Singh R K, ali S, Mobeen F, Khan FI. The effect of diffused drug and noise in the stochastic model of rat hepatocytes. J Nat Sc Biol Med [serial online] 2011 [cited 2020 Aug 11 ];2:105-105
Available from: http://www.jnsbm.org/text.asp?2011/2/3/105/96199


Full Text

We study stochastic model of drug (Methylprednisolone) diffusion in rat hepatocytes and the impact of diffused drug in the cellular processes. The simple model involves various protein-protein interaction and protein-drug interaction pathways. We used stochastic simulation algorithm due to Gillespie in order to simulate the temporal dynamics of various proteins and drugs involved in these interaction. We found that the dynamics of mRNA and receptor (R) to be saturated after sometime (~10-20 hours). We also found that the decrease in drug population systematically as a function of time. Further we studied how the dynamics of each protein changes as a function of system size (V) and found that the population of each protein increases as V increases. Noise is always involved with each protein and drug dynamics.