ORIGINAL ARTICLE
Year : 2020  |  Volume : 11  |  Issue : 1  |  Page : 17-20

Analysis of hematological metal element levels in orthopedic patients with implants


Institute of Orthopaedics and Traumatology, Coimbatore Medical College and Hospital, Coimbatore, Tamil Nadu, India

Correspondence Address:
Prof. Vetrivel Chezian Sengodan
Director of Institute of Orthopaedics and Traumatology, Coimbatore Medical College and Hospital, Coimbatore - 641 018, Tamil Nadu
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jnsbm.JNSBM_120_19

Rights and Permissions

Background: The progressive increase in concentration of circulating metal by-products derived from the metal-based orthopedic implants may have deleterious effects in the patients over the long term. Therefore, it is necessary to profile the metal levels in the body of the patients receiving metal implants using appropriate highly sensitive techniques and strategies. Hence, in this study, we estimated the levels of metal in serum of patients with metal implants. Materials and Methods: Blood samples of 25 patients with metallic implants were collected at 6 months postsurgery. The blood samples were subjected to triple acid digestion and then analyzed through inductively coupled plasma–mass spectroscopy, and the blood levels of various metals were quantified. Results: An increase in serum levels of titanium was observed in the patients with metal implants at 6 months postsurgical implant. However, the levels of titanium were within the normal range (normal level <7.2 μg/l), and we did not observe any signs of detectable systemic toxicity. In contrast, the mean serum levels of cobalt (0.19–2.6 μg/l) and nickel (0.05–1.08 μg/l) were above the normal range. Conclusion: Orthopedic patients with metal implants had the serum levels of titanium within the normal range but had serum levels of cobalt and nickel above the normal range. Despite increase in the serum levels of cobalt and nickel, the patients did not show any clinical signs of toxicity.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed329    
    Printed23    
    Emailed0    
    PDF Downloaded73    
    Comments [Add]    

Recommend this journal