ORIGINAL ARTICLE
Year : 2019  |  Volume : 10  |  Issue : 3  |  Page : 113-117

IIIB-plus: A new classification recommended for stage IIIB cervical cancer patients with renal impairment


1 Department of Obstetrics and Gynecology, Division of Gynecology Oncology, Faculty of Medicine, Dr. Cipto Mangunkusumo Central Hospital, Universitas Indonesia, Jakarta, Indonesia
2 Female Cancer Programme, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia

Correspondence Address:
Laila Nuranna
Staff Wing Building A, Level 3, Diponegoro Street No. 71, Kenari, Senen, Central Jakarta, Jakarta 10430
Indonesia
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jnsbm.JNSBM_53_19

Rights and Permissions

Objective: This study was designed to define the differences between Stage IIIB cervical cancer patients with and without renal impairment (RI), particularly with regard to the pathology results, laboratory values, therapies, and prognoses, in order to justify the need for separate classifications for these two different patient types. Materials and Methods: A retrospective cohort technique was used to evaluate consecutive Stage IIIB cervical cancer patients from July 2010 to July 2015. The data collected included the age, parity, cancer cell type, pelvic wall involvement, hydronephrosis degree and bilateral involvement, laboratory values (urea, potassium, and creatinine), treatment modalities, 3-month postradiation treatment response, hospital stay duration, and 1-year survival rate. Results: The study patients included 102 Stage IIIB cervical cancer patients with RI and 204 individuals without RI. The results showed significant differences between individuals with and without bilateral pelvic wall involvement (100% vs. 68.1%, respectively), hydronephrosis degree (severe hydronephrosis incidences: 69% vs. 3.9%, respectively), bilateral hydronephrosis (96.5% vs. 6.9%, respectively), median urea level (148 vs. 22 mg/dl, respectively), median creatinine level (8.0 vs. 0.8 mg/dl, respectively), and median potassium level (5.8 vs. 3.9 mEq/L, respectively). The hazard ratio was 3.07 for the survival analysis. Conclusion: Cervical cancer patients with RI are faced with worst prognosis, and their treatment modalities are limited due to their renal comorbidities, resulting in lesser type of therapy modalities (such as chemotherapy procedure prohibition), longer hospital stays, and a lower survival rate. Therefore, a new classification for cervical cancer patients with kidney impairment, named Stage IIIB-plus, should be considered.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed324    
    Printed10    
    Emailed0    
    PDF Downloaded54    
    Comments [Add]    

Recommend this journal