ORIGINAL ARTICLE
Year : 2015  |  Volume : 6  |  Issue : 2  |  Page : 335-339

Toxic effects of Mn 2 O 3 nanoparticles on rat testis and sex hormone


1 Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2 Department of Biology, Payame Noor University, Isfahan, Iran
3 Young Researchers and Elite Club, Khorasgan Branch, Islamic Azad University, Isfahan, Iran

Correspondence Address:
Dr. Marziyeh Ajdary
Young Researchers and Elite Club, Khorasgan Branch, Islamic Azad University, Isfahan
Iran
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Source of Support: Expenses of this work were discharged by authors., Conflict of Interest: None


DOI: 10.4103/0976-9668.159998

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Background and Objective: The safety of Mn 2 O 3 nanoparticles (which are extensively used in industries) on male reproductive system is not known. Hence, we investigated the effects of Mn 2 O 3 nanoparticles on male reproductive system. Materials and Methods: A total of 40 Wistar adult male rats were randomly assigned to four groups of 10 rats each. Three groups received Mn 2 O 3 solution in concentrations of 100, 200, and 400 ppm orally for 14 days; the control group received equal volume of saline solution. Blood samples and testicles were collected for analysis. Results: Significant reduction in luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone, spermatogonial cells, primary spermatocyte, spermatid and Leydig cell was observed in the Mn 2 O 3 nanoparticles treated groups compared with controls. Conclusion: Mn 2 O 3 nanoparticles significantly reduce FSH, LH, and testosterone levels resulting in a significant reduction in testicular cytology.


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