ORIGINAL ARTICLE
Year : 2013  |  Volume : 4  |  Issue : 2  |  Page : 435-439

Liquid chromatographic determinations of meta-chlorobenzoic acid in bupropion hydrochloride


Department of Analytical Research Lab, Glenmark Generics Ltd, Glenmark Research Centre, Plot A - 607, TTC Industrial Area, MIDC, Mahape, Navi Mumbai, Maharashtra, India

Correspondence Address:
Sukumar Sinha
Glenmark Generics Ltd, Glenmark Research Centre, Navi Mumbai
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0976-9668.117018

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A simple, sensitive method for the determination of meta-chlorobenzoic acid in bupropion hydrochloride is described. Chromatographic separation of m-chlorobenzoic acid is achieved using a mobile phase consisting of n-hexane and ethanol (1000:50, v/v) at a flow rate of 1.0 ml/min on a Chiralpak ADH (250 × 4.6 mm). Absorbance is monitored at 235 nm. The method is linear for m-chlorobenzoic acid over concentration range of LOQ, 5.0 μg/ml to 15.0 μg/ml for m-chlorobenzoic acid with correlation coefficient greater than 0.99. This method is more selective and accurate than United States Pharmacopoeia method for the determination of m-chlorobenzoic acid in bupropion hydrochloride.


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