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Year : 2011  |  Volume : 2  |  Issue : 3  |  Page : 152  

DNA polymorphism: A biologically relevant phenomenon


Department of Chemistry University of Delhi, Delhi 110 007, India

Date of Web Publication26-May-2012

Correspondence Address:
Shrikant Kukreti
Department of Chemistry University of Delhi, Delhi 110 007
India
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Source of Support: None, Conflict of Interest: None


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How to cite this article:
Kukreti S. DNA polymorphism: A biologically relevant phenomenon. J Nat Sc Biol Med 2011;2, Suppl S1:152

How to cite this URL:
Kukreti S. DNA polymorphism: A biologically relevant phenomenon. J Nat Sc Biol Med [serial online] 2011 [cited 2020 Feb 24];2, Suppl S1:152. Available from: http://www.jnsbm.org/text.asp?2011/2/3/152/96288

Nucleic acids (DNA/RNA) are the functional forms of polynucleotides. For years after description of the right-handed DNA double helix by Watson and Crick, DNA was viewed as uniform molecule. But considering the sequence - dependent, pH & cation - dependent, structural variations in solution, the concept of a monotonous double helix is no more in celebration at present times. Sequence dependent structural heterogeneity in the conformation, play a critical role in monitoring interactions of nucleic acids with both large and small substrates. Possibility of Intramolecular triplexes and quadruplexes acting as gene regulatory elements, have further enriched our understanding of nucleic function. Perhaps equally importantly, they provide new opportunities for intervention leading to further mechanistic understanding and therapeutic gain.

I will discuss here in brief, how the sequence, cation-type and solution pH dictates the conformational flexibility of DNA and generation of a galaxy of unimolecular to multistranded helices. Polymorphism of DNA is important for interactions with proteins or drugs.[3]

 
   References Top

1.Kaushik, M., Kaushik, S., Bansal, A., Saxena, S., Kukreti, S. Current Molecular Medicine 2011 , 9, (in press)  Back to cited text no. 1
    
2.Kaushik, M., Kaushik, S., Svinarchuk F, Malvy C, Fermandjian S, S. Kukreti Biochemistry, 2011 , 50, 4132-4142.  Back to cited text no. 2
    
3.Kukreti, S., Kaur, H., Kaushik, M., Bansal, A., Saxena, S., Kaushik, S., Kukreti, R. Biochimie 2010 , 92, 1199-1206.  Back to cited text no. 3
    




 

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