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Year : 2011  |  Volume : 2  |  Issue : 3  |  Page : 131-132  

Heterocyclic azoles and their biological application as antimicrobials


1 Centre for interdisciplinary research in basic sciences, Jamia Millia Islamia, New Delhi-110025, India
2 School of Biotechnology, Yeungnum University, Gyeongsan 712-749, Korea

Date of Web Publication26-May-2012

Correspondence Address:
Mohammad Arshad
Centre for interdisciplinary research in basic sciences, Jamia Millia Islamia, New Delhi-110025
India
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Source of Support: None, Conflict of Interest: None


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How to cite this article:
Arshad M, Tazeem, Bhat A R, Athar F. Heterocyclic azoles and their biological application as antimicrobials. J Nat Sc Biol Med 2011;2, Suppl S1:131-2

How to cite this URL:
Arshad M, Tazeem, Bhat A R, Athar F. Heterocyclic azoles and their biological application as antimicrobials. J Nat Sc Biol Med [serial online] 2011 [cited 2020 Feb 24];2, Suppl S1:131-2. Available from: http://www.jnsbm.org/text.asp?2011/2/3/131/96258

Compounds incorporating heterocyclic ring systems continue to attract considerable interest due to the wide range of biological activities they possess. Amongst them five membered heterocyclic compounds particularly azoles occupy a unique place in the realm of natural and synthetic organic chemistry. Keeping in mind the importance of azoles we have synthesized different series of compounds. Structure elucidation of all the synthesized compounds was done using different spectroscopic techniques such as FTIR, 1 H-NMR, 13 C-NMR, UV-VIS, Mass and Elemental analysis. In vitro antimicrobial screening of all the synthesized compounds was performed against gram positive and gram negative bacteria. The MIC was detected using the double dilution method. The results were compared by calculating percent inhibit area/mg of the compounds and the standard "amoxicillin". The selected compounds were tested for cytotoxic results using MTT assay H9c2 cardiac myoblasts cell line and the results showed that all the compounds offered remarkable >80% viability to a concentration of 200 mg/mL.




 

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