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Year : 2011  |  Volume : 2  |  Issue : 3  |  Page : 106  

Impact of high level glucose on P53-Mdm2 dynamics and intercellular communication


Centre for Interdisciplinary Research in Basic Science, Jamia Millia Islamia, New Delhi-110025, India

Date of Web Publication26-May-2012

Correspondence Address:
R K Brojen Singh
Centre for Interdisciplinary Research in Basic Science, Jamia Millia Islamia, New Delhi-110025
India
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Source of Support: None, Conflict of Interest: None


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How to cite this article:
Fatima N, Fatima S, Alam M, Devi GR, Ravins, Brojen Singh R K. Impact of high level glucose on P53-Mdm2 dynamics and intercellular communication. J Nat Sc Biol Med 2011;2, Suppl S1:106

How to cite this URL:
Fatima N, Fatima S, Alam M, Devi GR, Ravins, Brojen Singh R K. Impact of high level glucose on P53-Mdm2 dynamics and intercellular communication. J Nat Sc Biol Med [serial online] 2011 [cited 2020 Aug 11];2, Suppl S1:106. Available from: http://www.jnsbm.org/text.asp?2011/2/3/106/96200

We investigate the role of high glucose concentration level which leads to many functional changes in the cell and production of different types of oxidative molecules which in turn cause DNA damage leading to p53 activation. Our results show the DNA damage caused by high level glucose concentration level via activating reactive oxygen species (ROS) and put the cell in different stressed conditions depending on the glucose concentration levels. Further we take two stressed cells caused via glucose concentration level and allow coupled via diffusive coupling of this glucose itself. We found synchronization of the two coupled cells achieved at a particular value of the coupling constant. We further claim that glucose can activate p53 as well as act as synchronizing agent.




 

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