Table of Contents    
ORIGINAL ARTICLE
Year : 2011  |  Volume : 2  |  Issue : 2  |  Page : 209-210  

(pro)renin receptor: A stable molecule


Wiwanitkit House, Bangkhae, Bangkok, Thailand

Date of Web Publication27-Jan-2012

Correspondence Address:
Viroj Wiwanitkit
Wiwanitkit House, Bangkhae, Bangkok 10160
Thailand
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0976-9668.92321

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   Abstract 

Background: Basically, (pro)renin acts via a specifi c receptor, (pro)renin receptor (PRR) binding between renin and prorenin, its inactive proenzyme form. The study on the molecular level of PRR can give useful knowledge to help understand many renal disorders. Method: Here, the author focuses on the stability of the PRR molecule. The mutation prone positions within the PRR molecule was assessed using standard reference technique. Result: The study showed there is no identifi ed mutation prone position within the PRR molecule. Conclusion: This imply the high stability of PRR. This means that PRR rarely undergoes mutation. The reported mutation in PRR should be a very rare episode and the study on the specifi c cause is warranted.

Keywords: (pro)renin receptor, mutation


How to cite this article:
Wiwanitkit V. (pro)renin receptor: A stable molecule. J Nat Sc Biol Med 2011;2:209-10

How to cite this URL:
Wiwanitkit V. (pro)renin receptor: A stable molecule. J Nat Sc Biol Med [serial online] 2011 [cited 2020 Feb 20];2:209-10. Available from: http://www.jnsbm.org/text.asp?2011/2/2/209/92321


   Introduction Top


Renin system is a well-known biochemical system that plays an important role in the renal system of human beings. At present, the focus is shifting from renin to (pro)renin. Actually, (pro)renin acts via a specific receptor, (pro)renin receptor (PRR) binding between renin and prorenin, its inactive proenzyme form. [1],[2] The receptor-bound prorenin leads to generation of an enzymatic activity that activates the mitogen-activated protein (MAP) kinase ERK1/2 and p38 pathways and, subsequently, upregulation of profibrotic and cyclo-oxygenase-2 genes, independent of angiotensin II generation. [2] Inhibition of PRR can lead to inhibition of renin and be useful for treatment of many renal disorders. [3] The study of PRR on a molecular level can yield useful knowledge to help understand many renal disorders. [3] In addition, new evidences show the important role of PRR in hypertension and cardiovascular disease. [4],[5] A linkage between polymorphism of PRR and hypertension has also been shown. [5]

Here, the author focuses on the stability of the PRR molecule. Detection of the mutation prone position within the PRR molecule is done by a standard referencing bioinformatics approach.


   Materials and Methods Top


The mutation prone positions within the PRR molecule was assessed using standard reference technique; the technique was first proposed by Wiwanitkit. [6] Briefly, a search for the sequence of PRR in standard molecule database was performed. Subsequently, a bioinformatics tool, GlobPlot, was used for finding the mutation prone position within the derived PRR sequence. The protocol in this work is standard protocol acceptable and used in many previously published papers. [6],[7],[8],[9],[10],[11],[12]


   Results Top


The study showed that there is no identified mutation prone position within the PRR molecule.


   Discussion Top


PRR was discovered about 20 years ago. [13] Cousin et al. [14] reported that there were evidences for a correlation between polymorphism in the PRR gene and increased ambulatory blood pressure. Nevertheless, a mutation in the PRR gene that is responsible for mental retardation and epilepsy is also mentioned. [14],[15],[16] The study on the genetic stability of PRR is useful for improving our knowledge on molecular pathogenesis of kidney and other diseases (eg, hypertension, cardiovascular disease, cancer, etc [4] ).

Based on this study, it can be noted that there is no predicted mutation prone position within the PRR. This implies the high stability of PRR. Therefore, PRR rarely undergoes mutation. Indeed, this can be a good explanation for the question: "Why there are only a few reports on mutation of PRR?" The reported mutation in PRR should be a rare episode and a study on the specific cause is warranted. Finally, it should be noted that although this is a standard informatics study, this is only a predictive study using a predictive tool. The result predicted as a mutated position by the tool might not completely lead to the final expression. Hence, even if any point is identified, it may not result in expression of sense mutation.

 
   References Top

1.Ichihara A, Ito H. Prorenin/renin and the (pro) renin receptor in the kidney. Nippon Jinzo Gakkai Shi 2010;52:106-9.  Back to cited text no. 1
[PUBMED]    
2.Nguyen G, Muller DN. The biology of the (pro)renin receptor. J Am Soc Nephrol 2010;21:18-23.  Back to cited text no. 2
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3.Komers Rnone . What is the role of renin inhibition in the treatment of diabetic kidney disease? Curr Diab Repnone 2009;9:447-52.  Back to cited text no. 3
    
4.Nguyen G. Renin, (pro)renin and receptor: An update. Clin Sci (Lond)none 2011;120:169-78.  Back to cited text no. 4
    
5.Nguyen G. Renin and prorenin receptor in hypertension: What's new? Curr Hypertens Rep 2011;13:79-85.  Back to cited text no. 5
[PUBMED]  [FULLTEXT]  
6.Wiwanitkit V. Where is the weak linkage in the globin chain? Int J Nanomedicine 2006;1:109-10.  Back to cited text no. 6
[PUBMED]  [FULLTEXT]  
7.Wiwanitkit V. Identification of mutation-prone points in bile salt export pump. HPB (Oxford).none 2007;9:444-6.  Back to cited text no. 7
    
8.Wiwanitkit V. Mutation-prone points in thrombin receptor. J Thromb Thrombolysisnone 2008;25:190-2.  Back to cited text no. 8
    
9.Wiwanitkit V. Mutation-prone positions within the estrogen receptor. Taiwan J Obstet Gynecol 2009;48:130-2.  Back to cited text no. 9
[PUBMED]  [FULLTEXT]  
10.Wiwanitkit V. Mutation-prone points in KCNQ. Exp Clin Cardiol 2008;13:139-40.  Back to cited text no. 10
[PUBMED]  [FULLTEXT]  
11.Wiwanitkit V. Weak linkage in androgen receptor: Identification of mutation-prone points. Fertil Steril 2009;91:e1-3.  Back to cited text no. 11
    
12.Wiwanitkit V. Weak linkage in hepatitis C PePHD: Identification of mutation prone point that can lead to failure of antiviral therapy for prevention of hepatocellular carcinoma. Asian Pac J Cancer Prev 2007;8:139-40.  Back to cited text no. 12
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13.Nguyen Gnone . Twenty years of the (pro)renin receptor. J Am Soc Hypertensnone 2008;2:59-63.  Back to cited text no. 13
    
14.Cousin Cnone , Bracquart Dnone , Contrepas Anone , Nguyen Gnone . Potential role of the (pro)renin receptor in cardiovascular and kidney diseases. J Nephrolnone 2010;23:508-13.  Back to cited text no. 14
    
15.Contrepas A, Walker J, Koulakoff A, Franek KJ, Qadri F, Giaume C, Corvol P, Schwartz CE, Nguyen G. A role of the (pro)renin receptor in neuronal cell differentiation. Am J Physiol Regul Integr Comp Physiol. 2009;297:R250-7.  Back to cited text no. 15
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16.Nguyen G, Contrepas A. Physiology and pharmacology of the (pro)renin receptor. Curr Opin Pharmacol 2008;8:127-3.  Back to cited text no. 16
[PUBMED]  [FULLTEXT]  




 

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