Year : 2011  |  Volume : 2  |  Issue : 2  |  Page : 188-192

Effects of water deprivation on behavioral Changes in BALB/c mice in hot humid climate of north east India

Division of Pharmaceutical Technology, Defence Research Laboratory, Post Bag No. 2, Tezpur - 784 001, Assam, India

Correspondence Address:
Pronobesh Chattopadhyay
Division of Pharmaceutical Technology, Defence Research Laboratory, Tezpur - 784 001, Assam
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0976-9668.92328

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Aim: Abnormalities in water balance are manifested as hyponatremia and hypernatremia and the present investigation shows the effect of water deprivation in hot and humid climatic condition of north eastern part of India. Methods: Twenty four BALB/c mice of either sex (weight 30-40 g) were used for a 13-week experiment to determine the effects of water deprivation on behavioral and physiological changes. Mice were divided into control group (I) (n = 8), given water ad libitum, water-deprivation male group (15 ml/day) (Group II, n=8) and water-deprivation female group (15 ml/day) (Group III, n=8). Results: The water deprivation mice shows significantly (P<0.05) deteriorated of reflex, progressive visual placement, emotional whereas body weight, grip strength and rectal temperature were significantly (P<0.05) increased as compared to the control group. This information is useful to those living or deployed in crisis situations where the water supply limited in a hot-humid climate.

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