MEDICINE
Year : 2010  |  Volume : 1  |  Issue : 1  |  Page : 53-56

Role of antibodies in cancer targeting


Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, Boston, MA, USA

Correspondence Address:
Husain Attarwala
Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, Boston, MA
USA
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0976-9668.71675

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The development of chemotherapeutic agents capable of specifically eliminating tumor cells has been a great challenge since these agents cannot differentiate between normal body cells and tumor cells. Enhanced elimination of cancer cells without affecting normal body cells can be achieved by developing strategies which can enable drug targeting. With recent advances in antibody engineering strategies, the development of different antibody-associated tumor-targeted delivery systems for chemotherapy, chemoprevention, and early cancer diagnosis has become possible. In this review, the role of antibodies for cancer diagnosis, chemoprevention, and chemotherapy will be discussed with an emphasis on recent advances in antibody engineering.


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